Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease

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Pharmacological Study on L-ornithine L-aspartate.

塩屋 明利 ・倉石 弘一 ・柿本 守夫 ・玉真 洋子 In a healthy subject, ammonia produced in the body is excreted by the kidney in the form of urea, the product of the urea cycle (1), or converted into substances useful for the body. In cases of hepatic disorders, on the other hand, blood ammonia level is known to increase (2-6). It is likely that ammonia in high concentrations interferes with the TCA cycle (7) and th...

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Non-alcoholic Fatty Liver Disease

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Non-Alcoholic Fatty Liver Disease

Results: The term “non-alcoholic fatty liver disease” covers cases of a wide spectrum of severity, ranging from bland fatty liver without any inflammation and with little or no tendency to progress all the way to non-alcoholic steato hepatitis (NASH) with inflammatory reactions and hepatocyte damage, with or without fibrosis. Some 5% to 20% of patients with NAFLD develop NASH, which undergoes a...

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Non-alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease describes a range of conditions caused by a build-up of fat within liver cells. It is very common and in many cases is linked to being obese or overweight. Most people with non-alcoholic fatty liver disease do not develop serious liver problems. In some people, the build-up of fat in the liver can lead to serious liver disease. However, all people with non-alco...

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ژورنال

عنوان ژورنال: Digestive Diseases

سال: 2018

ISSN: 0257-2753,1421-9875

DOI: 10.1159/000491429